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Zed (Jack Black) is a hunter and Oh (Michael Cera) is a gatherer. After being informed that Zed ate from the Tree of Knowledge of Good and Evil, the shaman banishes him from the tribe. Oh decides to go with Zed on his journey to find the end of the Earth. Along the way, they encounter Cain and Abel (David Cross and Paul Rudd). Cain kills Abel and informs Zed and Oh that they must escape with him or else be accused of killing Abel.